BrainOmics – computational approaches to single-cell multi-omics in neuroscience

Category: Course

Location: Human Technopole, Milan, Italy

Date: 18/11/2024 – 22/11/2024

Fee: 700 € (Academic), 1500 € (Industry)

Target Audience: The course is open to up to 20 scientists. Participants are expected to be mostly bioinformaticians and computational biologists with (at least) a basic knowledge of omics techniques. The fee includes all costs related to the on-site activities (including a workstation for each participant), and meals. Accommodation is not included.

Image: Human cortical brain organoids at 50 days of differentiation displaying the typical rosette-like structures characteristic of the developing human brain. Credits: Aurelio Ortale, Oliviero Leonardi (Testa Group, HT).

Course Overview

BrainOmics 2.0 represents a unique interdisciplinary hands-on course on single-cell multi-omics computational analysis with a focus on the brain and its disorders and builds on the experience of the 2022 edition, with the addition of integrative sessions on functional genomics.

Single-cell omics technologies are breaking new ground in neurobiology by substantially increasing the precision and resolution with which the complex cell populations of the nervous system can be characterised. Approaches that profile several layers of information (genome, epigenome, transcriptome, proteome, spatial location) allow to generate data of unprecedented depth on the molecular state of the diversity of cells composing the nervous system.

This increase in data volume and complexity generates as many opportunities as new analytical challenges.

This compact course aims at empowering participants in mastering key computational tools for the analysis of single-cell omics datasets, starting from individual molecular layers to then tackle their integration, alongside providing a theoretical overview of the impact of these technologies at the leading edge of neurobiology.

Target Audience

This course is aimed at bioinformaticians and computational biologists with expertise or interest in neurobiology and (at least) a basic knowledge of omics techniques.

The core of the course will be centred around hands-on data analysis sessions. A basic understanding of Unix command line, Python and/or R is required. Previous experience with single-cell analytical workflows will be considered as an added value to harness the most from the course training sessions.

SCIENTIFIC ORGANISERS

Piero Carninci
Head of Functional Genomics Research Centre & Group Leader, HT (IT)
Cristina Cheroni
Senior Manager – Cell Reference Brain Atlas Scientific Service Unit, Neurogenomics, HT (IT)
Ivano Legnini
Group Leader, Functional Genomics, HT (IT)
Elena Taverna
Group Leader, Neurogenomics, HT (IT)
Giuseppe Testa
Head of Neurogenomics & Research Group Leader, HT (IT)

SPEAKERS & INSTRUCTORS

Nicolò Caporale
Postdoctoral Associate, HT (IT) – Instructor
Davide Castaldi
Postdoc, HT (IT) – Instructor
Cristina Cheroni
Senior Manager, HT (IT) – Organiser & Instructor
Rebecca Hodge
Assistant Investigator, Allen Institute for Brain Science (USA) – Speaker
Chung Chau Hon
Group Leader, RIKEN Centre for Integrative Medical Sciences (JP) – Speaker + Instructor
Joshua Levin
Group Leader, Broad Institute of MIT & Harvard (USA) – Speaker
Chong Li
Postdoc, Institute of Molecular Biotechnology (AT) – Speaker & Instructor
Sten Linnarsson
Professor, Karolinska Institutes (SE) – Speaker
Joakim Lundberg
Professor, SciLifeLab (SE) – Speaker
Ahmed Mahfouz
Assistant Professor, Leiden University Medical Center (NL) – Speaker & Instructor
Valeriya Malysheva
Group Leader, VIB-UAntwerp Center for Molecular Neurology (BE) – Speaker
Benedetta Manzato
PhD Student, Leiden University Medical Center (NL) – Instructor
Gaja Matassa
PhD Student, HT (IT) – Instructor
Nikolaus Rajewsk
Group Leader, Max Delbrück Center (DE) – Speaker
Nenad Sestan
Professor & Executive Director of the Genome Editing Center, Yale School of Medicine (USA) – Speaker
Genevieve Lauren Stein-O’Brien
Assistant Professor, Johns Hopkins University - School of Medicine (USA) – Speaker
Alessia Valenti
PhD Student, HT (IT) – Instructor
Emanuele Villa
Senior Staff Scientist, HT (IT) – Instructor
Alessandro Vitriolo
Postdoctoral Associate, HT (IT) – Instructor

Contact

Call for Sponsorship No.05 - BrainOmics course 2024: computational approaches to single-cell multi-omics in neuroscience